6495D LC/TQ coupled to the 1290 Infinity III LC?
6495D Triple Quadrupole LC/MS
The 6495D triple quadrupole LC/MS system is an ultrahigh-performance system built for research and testing labs investigating large batches of samples. Equipped with the latest, innovative iFunnel technology, this LC/MS/MS achieves ppq-level detection limits for the most challenging analytes in heavy matrix, for example in omics, food, and environmental analysis, while providing high precision at sub-millisecond dwell times.
Ultimate mass spectrometry performance is complemented by built-in instrument intelligence designed for demanding, nonstop routine analysis. Features including AI-based SWARM tuning, VacShield, early maintenance feedback (EMF) dashboard, scheduled tune, and intelligent reflex ensure that the system stays productive longer at peak performance, giving you peace of mind. An optional oil free dry pump delivers unparalleled energy efficiency, further improving the bottom line of your business.
Ultimate mass spectrometry performance is complemented by built-in instrument intelligence designed for demanding, nonstop routine analysis. Features including AI-based SWARM tuning, VacShield, early maintenance feedback (EMF) dashboard, scheduled tune, and intelligent reflex ensure that the system stays productive longer at peak performance, giving you peace of mind. An optional oil free dry pump delivers unparalleled energy efficiency, further improving the bottom line of your business.
Product Details
Features
- NEW: Edwards nXL200i enhanced oil free dry pump option, delivering over 50% savings in energy consumption and heat dissipation
- Fourth generation, innovative iFunnel technology captures more of the ESI plume during ionization, resulting in dramatic improvement of signal response and detection limit compared to non-iFunnel systems
- SWARM autotune obtains the absolute best system settings using a multifactorial optimization artificial intelligence algorithm
- Intelligent reflex workflows provide data-dependent sample reinjection protocols that focus on sample assurance or improvements in sample throughput
- VacShield enables quick and easy cleanup of matrix deposits without venting the system
- Scheduled tuning alleviates the burden of routine maintenance, so you know that the mass spectrometer is always at peak performance
- Early maintenance feedback provides an easy-to-read dashboard to help visualize LC/MS instrument health and anticipate upcoming maintenance events
- Application-focused tuning and workflows facilitate analysis and quantitation of lipids, metabolites, peptides, proteins (digested), PFAS, and pesticides
- Compound optimizer allows fast method development by enabling users to create methods or add new compounds to an existing method, with automatic tuning to develop an optimal MRM transition for each new compound
- Seamless method transfer between Agilent LC/MS instruments on MassHunter 12 or higher shortens method development time and eases the burden of moving methods from system to system
How It Works
Applications
Featured References
- Publications
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- Single-Sample, Multiomic Mass Spectrometry for Investigating Drug Effects and Mechanisms. Iqbal Mahmud, Wai-Kin Chan, Karen Yannell, Cate Simmermaker, Genevieve C. Van de Bittner, Linfeng Wu, Daniel Chan, Sheher Banu Mohsin, Yiwei Liu, John Sausen, John N. Weinstein, and Philip L. Lorenzi. Journal of Proteome Research, ASAP, July 29, 2025. Learn More
- Cysteine-S-sulfate promotes arteriosclerosis obliterans by inducing TH17 differentiation and promoting pyroptosis. Yujie Jiang, Xia Feng, Yuan Yin, Chao Ma, Jie Deng, Hao Yin, Jian Chen, Yicheng Xu, Tianhua Yan, Yeming Cao, Yongbing Cao, Qun Lu, and Chenglin Jia. International Immunopharmacology 2025, 160, 114951 Learn More
- SysQuan: Repurposing SILAC Mice for the Cost-Effective Absolute Quantitation of the Human Proteome. Yassene Mohammed, Vincent R. Richard, M. Immanuel Reyes Madlangsakay, Ying Lao, Victor Spicer, Robert Popp, Claudia Gaither, Laura Hennecken, Wolfgang Kleinekofort, René P. Zahedi, and Christoph H. Borchers. Molecular & Cellular Proteomics 2025, 24(6), 100974. Learn More
- Targeting PIKfyve-driven lipid metabolism in pancreatic cancer. Caleb Cheng, Jing Hu, Rahul Mannan, Tongchen He, Rupam Bhattacharyya, Brian Magnuson, Jasmine P. Wisniewski, Sydney Peters, Saadia A. Karim, David J. MacLean, Hüseyin Karabürk, Li Zhang, Nicholas J. Rossiter, Yang Zheng, Lanbo Xiao, Chungen Li, Dominik Awad, Somnath Mahapatra, Yi Bao, Yuping Zhang, Xuhong Cao, Zhen Wang, Rohit Mehra, Pietro Morlacchi, Vaibhav Sahai, Marina Pasca di Magliano, Yatrik M. Shah, Lois S. Weisman, Jennifer P. Morton, Ke Ding, Yuanyuan Qiao, Costas A. Lyssiotis, and Arul M. Chinnaiyan. Nature 2025, 642, 776–784. Learn More
- Pantothenate kinase 4 controls skeletal muscle substrate metabolism. Adriana Miranda-Cervantes, Andreas M. Fritzen, Steffen H. Raun, Ond?ej Hodek, Lisbeth L. V. M?ller, Kornelia Johann, Luisa Deisen, Paul Gregorevic, Anders Gudiksen, Anna Artati, Jerzy Adamski, Nicoline R. Andersen, Casper M. Sigvardsen, Christian S. Carl, Christian T. Voldstedlund, Rasmus Kj?bsted, Stefanie M. Hauck, Peter Schjerling, Thomas E. Jensen, Alberto Cebrian-Serrano, Markus J?hnert, Pascal Gottmann, Ingo Burtscher, Heiko Lickert, Henriette Pilegaard, Annette Schürmann, Matthias H. Tsch?p, Thomas Moritz, Timo D. Müller, Lykke Sylow, Bente Kiens, Erik A. Richter, and Maximilian Kleinert. Nature Communications 2025, 16, 345 Learn More
- A Comprehensive LC–MS Metabolomics Assay for Quantitative Analysis of Serum and Plasma. Lun Zhang, Jiamin Zheng, Mathew Johnson, Rupasri Mandal, Meryl Cruz, Miriam Martínez-Huélamo, Cristina Andres-Lacueva, and David Wishart. Metabolites 2024, 14(11), 622 Learn More
