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This application note demonstrates the comprehensive sequence analysis and localization of modifications in three synthetic GLP-1 analogs.
This guide provides information about the ExD cell and ExDControl software.
This document is an information guide and checklist prepared for you that outlines the supplies, space, and utility requirements for the system set up in your lab.
This note shows identification of isobaric residues in peptides and intact proteins with 6545XT AdvanceBio LC/Q-TOF and ExD cell electron capture dissociation.
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| Japanese (Japan) | Complete (PDF) |
Ultimate flexibility for more informed decisions. One instrument and multiple workflows for biopharma.
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| Korean (Korea) | Complete (PDF) |
In this study we demonstrate in-depth LC-MS/MS sequence and modification characterization of multiple GLP-1 receptor agonists by implementing electron capture dissociation and ExDViewer for fragment analysis.
In-source chemical charge reduction allows precise control over protein charge distributions. This work explores the influence of charge reduction on protein structure and top-down fragmentation.
ExDViewer is a flexible fragment analysis software that enables streamlined characterization of synthetic peptide sequences. Here, we highlight key features such as customizable fragmentation rules that were key for analyzing biomimetic peptoid ECD...
These experiments demonstrate the capabilities of the Agilent 6545XT AdvanceBio LC/Q-TOF with the ExD cell to do “middle-down” characterization of antibodies.
Here, we employ top-down ECD MS to characterize Bcl-xL, a protein central to cellular apoptosis. GCE was used to encode phosphorylation at Ser62, a key site that initiates apoptosis when phosphorylated.3 However, the mechanisms underlying this...
In this work we investigate ways to tune the CIU-IM-ECD-MS to yield practical ECD efficiency and IM resolution leveraging the prototype ExD cell to study the relationship between protein collision cross section (CCS) and sequence coverage by ECD.
Here we introduce the ability to?confirm?multiple?sequence?hypotheses?inside ExDViewer against a single TD mixture spectrum.
This poster introduces a chemical charge stripping method to lower the number of charge states with a hope to maintain the unfolded protein structure.
This work highlights the unbiased deconvolution method in ExDViewer software showing excellent performance on TDMS/native TDMS (nTDMS) data from an array of peptides and proteins ranging from 1.4-150 kDa acquired on different instruments.
Here, we show the Agilent 6545XT AdvanceBio LC/Q-TOF with ExD cell enables glycopeptide analysis with excellent sequence coverage assessed using MassHunter BioConfirm 12.1.