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Describes a workflow for monitoring multiple mAb characteristics involving the Agilent 1290 Infinity II 2D-LC System.
This app note presents a high-throughput workflow that enables simultaneous, highly reproducible sample digestion and cleanup.
| Korean (Korea) | Complete (PDF) |
|---|---|
| Japanese (Japan) | Complete (PDF) |
| Chinese (Simplified) (China) | Complete (PDF) |
In this application note, we are investigating an antibody drug conjugate (ADC) with a cysteine linker. The Agilent 1290 Infinity II liquid chromatography system connected to a PLRP-S reversed phase liquid chromatography column was used to separate...
| Korean (Korea) | Complete (PDF) |
|---|---|
| Chinese (Simplified) (China) | Complete (PDF) |
Analysis of an mAb (trastuzumab) and an ADC (trastuzumab emtansine) by size exclusion chromatography with online mass spectrometry (SEC-MS)
本文詳細(xì)的介紹了蛋白（肽段）定量的意義及出現(xiàn) MRM 質(zhì)譜技術(shù)平臺(tái)的緣由、MRM 肽段定量的基本原理、安捷倫 MRM 肽段定量的完整定義以及安捷倫 LC/QQQ 肽段定量應(yīng)用實(shí)例等。
本文以半胱氨酸連接的抗體藥物偶聯(lián)物 (ADC) 為研究對(duì)象，使用天然質(zhì)譜法，通過(guò) Agilent 6530 Q-TOF LC/MS 檢測(cè) ADC 的完整分子量，并使用安捷倫 DAR 計(jì)算器軟件計(jì)算 ADC 的加權(quán)平均藥物/抗體比率(DAR)。
本文介紹了使用 Agilent 6530 Q-TOF 采集肽段數(shù)據(jù)， 采用整合有 BioConfirm 的 MassHunter 定性軟件，通過(guò)軟件中的蛋白酶解產(chǎn)物比較功能，實(shí)現(xiàn)了對(duì)單克隆抗體藥物中二硫鍵連接的確證。此方法無(wú)需對(duì)樣品進(jìn)行額外的標(biāo)記，僅通過(guò)對(duì)還原和非還原組樣品的一級(jí)質(zhì)譜進(jìn)行比對(duì)，即可實(shí)...