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Dr. Chris Denning discusses short stories around his research, particularly around the use of Cas9/CRISPR to modify the genome of hiPSC-CMs, with applications of Seahorse XF and CardioECR to understand variation in the human population.
xCELLigence RTCA- impedance biosensors to continuously monitor changes in cell number, cell morphology, cell-substrate attachment strength, and cell barrier function. Track the same population of cells via three-color live cell imaging.
In this webinar, Dr. Roddy O’Connor will discuss how T cells can be genetically modified with synthetic receptors “CARs” that redirect their specificity against distinct tumor antigens.
The rate of cellular ATP production is a powerful and straightforward measurement of energy metabolism. This webinar will discuss how OCR and ECAR can be easily converted into rates of mitochondrial and glycolytic ATP production. This routine method...
Leukemia is a cancer of the body's blood-forming tissues, including bone marrow (Acute myeloid leukemia-AML) and the lymphatic system (Acute lymphatic leukemia-ALL). From a metabolic perspective, acquired chemoresistance is associated with a shift...
Dr. Yuting Sun discusses her research supporting a Phase 1 clinical trial advancing cancer therapies, targeted at metabolic vulnerabilities. Strategies in targeting two metabolic vulnerabilities-FHmut cancer and glycolysis-deficient cancer.
Dr. John Connolly, Tessa Therapeutics, will present a novel flow cytometry-based method to demonstrate the importance of metabolic change in memory T cell differentiation, highlight these factors as attributes of adoptive T cell therapy.
In this webinar, Dr. Olaf Groß will discuss a link between metabolism and NLRP3 which has long been postulated and is supported by in vivo evidence and inhibitor data.
Introducing the XF Substrate Oxidation Stress Tests, a robust portfolio of XF assays enabling insights into cellular substrate dependencies to identify specific mitochondrial substrates that are relevant for cellular phenotype and function.
In this webinar, Julie Eakins, Senior Research Scientist at ADME-Tox Specialists Cyprotex, will discuss a number of in vitro approaches to detect compounds which can result in mitochondrial toxicity. Using a combination of different assays on the...
In this webinar, Dr. Sandra Milasta, Senior Scientist of Elevatebio will discuss how metabolic pathways maintain lymphocyte survival, drive memory vs. effector function, and the implications of these findings on the development of next generation T...
In this webinar, Dr. Jeffrey Rathmell will discuss mechanisms of metabolic reprogramming in T cell activation and differentiation. The tumor microenvironment and inflammatory cues influence T cell nutrient uptake and metabolism, and these pathways...
In this webinar, Dr. Stephen Black will discuss the link between the disruption of ?-oxidation and mitochondrial function in the development of pulmonary endothelial dysfunction. Pulmonary vascular disease is a serious complication for children born...
This webinar will discuss how we can selectively demolish intramural Tregs by targeting unique metabolic preference of intratumoral Tregs and how this approach can be utilized for cancer research.
In this webinar, Dr. Victor Darley-Usmar will introduce a new concept known as the bioenergetic-metabolite interactome, which describes how defining our bioenergetic health at the level of individual cells can now be achieved. Although we have known...
This webinar assesses the Seahorse XF platform as a tool for screening mitochondrial dysfunction and presents a workflow with reference to a panel of mitochondrial toxic drugs.
Presentation by Daniel Gebhard at the 4th German Pharma Tox Summit, Stuttgart, Germany, discussing workflows and case study examples of direct, real-time measurement of mitochondrial toxicity.