Developing analytical methods that produce robust and reliable quantitative data is particularly challenging in liquid chromatography for analytes with acidic or anionic functional groups. This is due to their propensity toward nonspecific binding, or interactions with the active metal sites in the flow path. These interactions lead to sample loss due to adsorption, sample carryover, inconsistent peak area from injection to injection, increased peak tailing, and decreased signal response—especially with LC/MS workflows.

Altura columns feature our innovative Ultra Inert technology. This advanced coating blocks active metal sites, ensuring an inert flow path while maintaining the strength, pressure tolerance, and consistency of a traditional stainless steel HPLC column.

The result? Altura columns unlock the true separation potential of the stationary phase. Experience superior chromatographic performance, faster equilibration, and enhanced sensitivity for your most challenging metal-sensitive analytes.

The initial release of Altura Ultra Inert HPLC columns includes reversed-phase and HILIC stationary phases for metal-sensitive analytes such as peptides, oligonucleotides, and polar metabolites.