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This guide is valid for MassHunter 12.1, until superseded.
This guide is valid for MassHunter 12.1, until superseded.
This guide provides instructions for installing or upgrading MassHunter Qualitative Analysis 13.0 and later, and MassHunter Quantitative Analysis 12.1 and later.
Streamlined workflows for N-Glycan analysis of biotherapeutics using Agilent AdvanceBio Gly-X InstantPC and 2-AB Express sample preparation with LC/FLD/MS
Release notes for MassHunter Acquisition for LC/QTOF.
This checklist provides information on how to prepare your site prior to installation for 6500 series LC/QTOF instruments.
A high-throughput, ion-pairing-free method for oligo characterization using Agilent RapidFire 400 and 6545XT QTOF system. The method uses MS-friendly, ammonium bicarbonate-based mobile phases and achieves a 12-second cycle time.
In this study we demonstrate in-depth LC-MS/MS sequence and modification characterization of multiple GLP-1 receptor agonists by implementing electron capture dissociation and ExDViewer for fragment analysis.
Charge variant shifts impact mAb stability. This report examines Mg2? (0.5 mM) effects on trastuzumab (IgG1). Mg2? is commonly used in biopharma formulations as an excipient (50–100 mM) and lubricant (5–10% w/w).
In this study, we present a heart-cutting 2D-LC/MS workflow utilizing the Agilent 1290 Infinity III Bio 2D- LC system coupled with the Agilent 6545XT AdvanceBio LC/Q-TOF for detailed impurity profiling and Comprehensive characterization of...
The 2D ProA CEX-MS method integrates direct titer and charge variant analysis into a single workflow, streamlining mAb biosimilarity assessment.
2D-LC enhances sensitivity in mAb analysis by detecting minor charge or conformational variations that single-method approaches miss. By integrating orthogonal separation, it provides a comprehensive characterization of mAb heterogeneity.
ExDViewer is a flexible fragment analysis software that enables streamlined characterization of synthetic peptide sequences. Here, we highlight key features such as customizable fragmentation rules that were key for analyzing biomimetic peptoid ECD...
This poster demonstrates a 2D-LC/Q-TOF approach to identify the free drug content of an ADC sample. The method combines size exclusion chromatography (SEC) in the first dimension (1D) and reversed-phase (RP) separation in the second dimension (2D).
How to write good SOPs and other QMS documents