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41 - 60 of 79 results
2D-LC enhances sensitivity in mAb analysis by detecting minor charge or conformational variations that single-method approaches miss. By integrating orthogonal separation, it provides a comprehensive characterization of mAb heterogeneity.
This poster demonstrates a 2D-LC/Q-TOF approach to identify the free drug content of an ADC sample. The method combines size exclusion chromatography (SEC) in the first dimension (1D) and reversed-phase (RP) separation in the second dimension (2D).
ExDViewer is a flexible fragment analysis software that enables streamlined characterization of synthetic peptide sequences. Here, we highlight key features such as customizable fragmentation rules that were key for analyzing biomimetic peptoid ECD...
In this study we demonstrate in-depth LC-MS/MS sequence and modification characterization of multiple GLP-1 receptor agonists by implementing electron capture dissociation and ExDViewer for fragment analysis.
In this work we evaluate four-dimensional feature finding algorithms (vendor and third party) as well as methods for aligning precursor and fragment ions across various chemical species including lipid, proteomics, and PFAS data.
Charge variant shifts impact mAb stability. This report examines Mg2? (0.5 mM) effects on trastuzumab (IgG1). Mg2? is commonly used in biopharma formulations as an excipient (50–100 mM) and lubricant (5–10% w/w).
Polysorbates are essential in biotherapeutic formulations but can degrade via oxidation and data analysis is challenging. A new LC/MS workflow featuring an innovative LC column and automated suspect screening software is introduced.
The 2D ProA CEX-MS method integrates direct titer and charge variant analysis into a single workflow, streamlining mAb biosimilarity assessment.
Untargeted LC-MS/MS lipidomics reveals tissue-specific lipid remodeling during aging. This workflow enables confident lipid ID, and quantification to uncover changes and metabolic shifts across liver, WAT, BAT tissues in mouse.
GC-SICRIT-QTOF is applied to aroma components analysis which is valuable in identification and profiling.
LC/Q-TOF technology and multilevel qualitative analysis effectively revealed the chemical composition differences in ginseng extract fermentation. This approach identified enhanced ginsenoside transformation, indicating potential bioactivity...
In this study, we present a heart-cutting 2D-LC/MS workflow utilizing the Agilent 1290 Infinity III Bio 2D- LC system coupled with the Agilent 6545XT AdvanceBio LC/Q-TOF for detailed impurity profiling and Comprehensive characterization of...
In-source chemical charge reduction allows precise control over protein charge distributions. This work explores the influence of charge reduction on protein structure and top-down fragmentation.
A professor of chemistry at the University of Michigan, Dr. Ruotolo and colleagues are looking for ways to make mass spectrometry analysis of macromolecules more quantitative and more information rich.
These experiments demonstrate the capabilities of the Agilent 6545XT AdvanceBio LC/Q-TOF with the ExD cell to do “middle-down” characterization of antibodies.
Here we are presenting a strategy combining a fast LC chromatography gradient using full spectra acquisition with Revident LC/Q-TOF and its excellent mass accuracy followed by automated data processing and reinjection with different...
Here we introduce Flash Characterization of mAbs with an automatic injector, combination treatments, and microdroplet reaction in the AJS source demonstrates simplification, reproducibility, and cost reduction of protein characterization.
The main goal of this study was to identify as many compounds as possible using a combination of tools including: retention time and accurate mass databases, NIST Tandem MS/MS libraries, SIRIUS and CSI:FingerID.?
This poster shows the entire workflow for non-targeted PFAS analysis is covered by FluoroMatch Flow.
This poster outlines the average and compound-specific mass accuracy differences observed as a function of concentration and overall analytical sensitivity (1 ppb- 100 ppb) using the Agilent Revident LC/Q-TOF. ?