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Critical Quality Attribute Monitoring of mAbs at the Intact and Subunit Levels
This app note presents a complete high-throughput workflow solution to analyze a variety of mAb products.
| Chinese (Simplified) (China) | Complete (PDF) |
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This application note demonstrates three approaches to quantitatively understand the glycosylation present for a given mAb.
Analysis of an mAb (trastuzumab) and an ADC (trastuzumab emtansine) by size exclusion chromatography with online mass spectrometry (SEC-MS)
本文介紹了使用 Agilent 6530 Q-TOF 采集肽段數(shù)據(jù)， 采用整合有 BioConfirm 的 MassHunter 定性軟件，通過軟件中的蛋白酶解產(chǎn)物比較功能，實(shí)現(xiàn)了對(duì)單克隆抗體藥物中二硫鍵連接的確證。此方法無需對(duì)樣品進(jìn)行額外的標(biāo)記，僅通過對(duì)還原和非還原組樣品的一級(jí)質(zhì)譜進(jìn)行比對(duì)，即可實(shí)...