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PLRP-S reversed-phase HPLC columns deliver the pure oligonucleotides required for genomic applications.
Direct 2D-LC analysis of oligonucleotides in solution with high salt content, with online desalting in the first dimension and IP-RPLC in the second dimension.
In this application note, we explore some of the key parameters when comparing different column chemistries using ion-pair reversed-phase (IP-RP) separation of Semaglutide.
Rapid mRNA capping analysis with a combined sample preparation and analysis time of only 75 minutes using an Agilent 6545XT AdvanceBio LC/Q-TOF.
This application note demonstrates the purification workflow of a single-stranded RNA ON by ion-pair reversed-phase HPLC.
Use of 6545XT LC/Q-TOF to analyze poly-A tail sequences formed by E. coli Poly-A Polymerase (PAP), which is a common component of in vitro transcription systems.
This application note shows that there are numerous variables available for optimization of the analytical conditions for oligonucleotides. The analyses were carried out on an Agilent 1290 Infinity II LC System with UV detection by DAD and an...
This app note presents a complete high-throughput workflow solution to analyze a variety of mAb products.
An Integrated Workflow for Intact and Subunits of Monoclonal Antibody Accurate Mass Measurements
Agilent PLRP-S column demonstrates superior separation performance for the analysis of mAbs and ADC at both intact and fragment levels
In this paper, we are investigating an antibody drug conjugate (ADC) with a cysteine linker.
AdvanceBio Oligonucleotide with UV and MS eluents is ideal for oligonucleotides, with exceptional resolution, superior lifetime, compatible with 600 and 1200 bar.
Explains IEX chromatography, column selection, mobile phase considerations, general rules of thumb for using IEX, and more.