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Identification of monoclonal antibody mutation sites using the 1290 Infinity II 2D-LC solution with 6530 Q-TOF LC/MS.
Presents the use of the AdvanceBio HIC column to resolve monoclonal antibody variants from their native form without mAb digestion into subunits.
This app note presents a complete high-throughput workflow solution to analyze a variety of mAb products.
Presents the use of AdvanceBio Desalting-RP cartridges to pretreat mAb and ADC samples before MS analysis.
Describes the use of the new AdvanceBio HIC column, with method optimization, to assess DAR values of ADCs.
An Integrated Workflow for Intact and Subunits of Monoclonal Antibody Accurate Mass Measurements
Agilent PLRP-S column demonstrates superior separation performance for the analysis of mAbs and ADC at both intact and fragment levels
Agilent Bio Mab WCX separates charged variants of papain-digest monoclonal antibody, following by MS characterization of the charged variants with online desalting.
An Agilent Bio-Monolith Protein A column determined recombinant mAb titer and was used to enrich μg amounts of antibody for further structural characterization by MS.
Workflow solutions for Optimizing Native ADC and mAb Analysis.
A Trio of Techniques to Complete CQA Characterization.