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1 - 12 of 12 results
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An exploration of how 2D-LC/MS/MS is used to quantitatively investigate chiral shift in the metabolism of propranolol and its hydroxy metabolites in human urine.
2D-LC/MS/MS analysis of drugs and their metabolites in a pharmacokinetic study, eliminating coelution and the risk of cross-talk for for a complex sample
Analysis of cytochrome P450 (CYP) inhibition is an important component of the drug discovery process as adverse drug-drug interactions can lead to termination of a drug development program, withdrawal from the market, or restrictions on therapeutic...
| Chinese (Simplified) (China) | Complete (PDF) |
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Agilent's RapidFire High-throughput Mass Spectrometry system utilizes the Q-TOF MS to speed up metabolic stability data analysis by eliminating the need for MRM optimization.
Research quantification of melatonin (MEL) with Agilent 1260 Infinity II Prime LC system coupled with Agilent Ultivo triple quadrupole LC/MS ESI source
| Chinese (Simplified) (China) | Complete (PDF) |
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A sensitive LC-MS/MS method has been developed for the simultaneous quantitation of a full panel of 26 antiepileptic drugs (AEDs).
This appnote demonstrates the advantages of using an Agilent 6470 QQQ coupled with an Agilent RapidFire 365 High-throughput MS System.
| Chinese (Simplified) (United States) | Complete (PDF) |
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Purification of metabolites using Agilent Automated Purification Software and identification using accurate mass data in Mass-MetaSite software is demonstrated.
At a rate of 10 seconds per sample, RapidFire/MS is suitable for ultrafast determination of IC50 curves of potential inhibitors of CYP3A4, CYP2C9, and CYP2D6
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Ocycodone and its oxidative metabolites are analyzed by high performance HPLC/MS coupled with chromatographic separation by an Agilent ZORBAX RRHT Stablebond SB-C18 column.
| Publication Part Number | 5990-3815EN | ||||
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The employment of a HRAM LC/MS approach for simultaneous quantitative and qualitative analysis was demonstrated for the bioanalysis and metabolite identification of clozapine
Application note for software-assisted, high-throughput identification of main metabolites of pharmaceutical drugs
| Chinese (Simplified) (China) | Complete (PDF) |
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