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Describes the use of the Agilent ChemStation Method Scouting Wizard in method development to separate and detect active compounds using SFC and TOF MS.
Analysis of cytochrome P450 (CYP) inhibition is an important component of the drug discovery process as adverse drug-drug interactions can lead to termination of a drug development program, withdrawal from the market, or restrictions on therapeutic...
Agilent's RapidFire High-throughput Mass Spectrometry system utilizes the Q-TOF MS to speed up metabolic stability data analysis by eliminating the need for MRM optimization.
Demonstrates simple and fast sample submission with the Agilent InfinityLab LC/MSD iQ for multiple users utilizing the sample purity workflow in an open-access environment.
Research quantification of melatonin (MEL) with Agilent 1260 Infinity II Prime LC system coupled with Agilent Ultivo triple
quadrupole LC/MS ESI source
At a rate of 10 seconds per sample, RapidFire/MS is suitable for ultrafast determination of IC50 curves of potential inhibitors of CYP3A4, CYP2C9, and CYP2D6