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This application note describes a robust LC/MS method for the analysis of native mAb-siRNA conjugates.
This app note presents a complete high-throughput workflow solution to analyze a variety of mAb products.
| Chinese (Simplified) (China) | Complete (PDF) |
|---|---|
| Japanese (Japan) | Complete (PDF) |
Presents the use of the Agilent Bio SEC-3 column to aid HRMS characterization of mAbs and ADCs.
Presents the use of AdvanceBio Desalting-RP cartridges to pretreat mAb and ADC samples before MS analysis.
Easy-to-use and fully integrated method for determination of DAR values for ADCs
| Korean (Korea) | Complete (PDF) |
|---|
In this application note, we are investigating an antibody drug conjugate (ADC) with a cysteine linker. The Agilent 1290 Infinity II liquid chromatography system connected to a PLRP-S reversed phase liquid chromatography column was used to separate...
| Korean (Korea) | Complete (PDF) |
|---|---|
| Chinese (Simplified) (China) | Complete (PDF) |
Using Automated Affinity Purification, LC/MS analysis, and Novel DAR Calculation Software
| Korean (Korea) | Complete (PDF) |
|---|
Using Multiple Heart-cutting Hydrophobic Interaction/Reversed Phase 2D-LC/MS
Analysis of an mAb (trastuzumab) and an ADC (trastuzumab emtansine) by size exclusion chromatography with online mass spectrometry (SEC-MS)
Here we introduce the ability to?confirm?multiple?sequence?hypotheses?inside ExDViewer against a single TD mixture spectrum.
Methods using Agilent AdvanceBio SEC columns are developed for the characterization of components of standard protein mixtures.
Methods using Agilent AdvanceBio SEC columns are developed for the characterization of components of standard protein mixtures.
本文以半胱氨酸連接的抗體藥物偶聯(lián)物 (ADC) 為研究對(duì)象，使用天然質(zhì)譜法，通過(guò) Agilent 6530 Q-TOF LC/MS 檢測(cè) ADC 的完整分子量，并使用安捷倫 DAR 計(jì)算器軟件計(jì)算 ADC 的加權(quán)平均藥物/抗體比率(DAR)。