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This application note demonstrates the benefits of the Agilent Cary 3500 UV-Vis Multicell spectrophotometer for analysis of drug-to-antibody ratio and aggregation index of ADCs.
| Korean (Korea) | Complete (PDF) |
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| Spanish (Spain) | Complete (PDF) |
| Japanese (Japan) | Complete (PDF) |
| French (France) | Complete (PDF) |
| Chinese (Simplified) (China) | Complete (PDF) |
| German (Germany) | Complete (PDF) |
| Italian (Italy) | Complete (PDF) |
This application note demonstrates the drug-to-antibody (DAR) determination of brentuximab vedotin using a ternary gradient with the Agilent Infinity II Prime Bio LC.
| Chinese (Simplified) (China) | Complete (PDF) |
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Comparing maps of a mAb and its conjugates with the AdvanceBio Peptide Mapping column identifies peptides conjugated with a cytotoxic drug in an ADC digest.
Analysis of tryptic digests of a monoclonal antibody and an antibody-drug conjugate with the Agilent 1290 Infinity II LC
In this application note, we have developed a mass spectrometry-compatible, native-mode size exclusion (SEC/MS) method for characterization of a challenging FDC with very low pI.
| German (Germany) | Complete (PDF) |
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| French (France) | Complete (PDF) |
| Spanish (Spain) | Complete (PDF) |
| Chinese (Simplified) (China) | Complete (PDF) |
| Italian (Italy) | Complete (PDF) |
| Korean (Korea) | Complete (PDF) |
| Japanese (Japan) | Complete (PDF) |
This application note demonstrates the DAR determination of brentuximab vedotin using HIC.
| Chinese (Simplified) (China) | Complete (PDF) |
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This application note describes a robust LC/MS method for the analysis of native mAb-siRNA conjugates.
This study determines the efficiency gains associated with using fluorescence analysis to complement size exclusion chromatography for aggregation analysis
Describes a comparison between the Agilent AdvanceBio SEC 200 ? 1.9 μm column and other vendors' SEC columns in terms of mAb and ADC analysis.
| Japanese (Japan) | Complete (PDF) |
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| Chinese (Simplified) (China) | Complete (PDF) |
This app note presents a complete high-throughput workflow solution to analyze a variety of mAb products.
| Chinese (Simplified) (China) | Complete (PDF) |
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| Japanese (Japan) | Complete (PDF) |
Presents the use of the Agilent Bio SEC-3 column to aid HRMS characterization of mAbs and ADCs.
Presents the use of AdvanceBio Desalting-RP cartridges to pretreat mAb and ADC samples before MS analysis.
Methods using Agilent AdvanceBio SEC columns are developed for the characterization of components of standard protein mixtures.
| Japanese (Japan) | Complete (PDF) |
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| Chinese (Simplified) (China) | Complete (PDF) |
Describes the use of the new AdvanceBio HIC column, with method optimization, to assess DAR values of ADCs.
| Japanese (Japan) | Complete (PDF) |
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| Chinese (Simplified) (China) | Complete (PDF) |
Determination of drug to antibody ratio of brentuximab vedotin using hydrophobic interaction chromatography on the Agilent 1260 Infinity II Bio-inert LC
This workflow guide focuses on the characterization of ADCs using multiple complementary approaches.
Easy-to-use and fully integrated method for determination of DAR values for ADCs
| Korean (Korea) | Complete (PDF) |
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In this application note, we are investigating an antibody drug conjugate (ADC) with a cysteine linker. The Agilent 1290 Infinity II liquid chromatography system connected to a PLRP-S reversed phase liquid chromatography column was used to separate...
| English (United States) | Complete (PDF) |
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| Korean (Korea) | Complete (PDF) |
| Chinese (Simplified) (China) | Complete (PDF) |
Agilent Zorbax RRHD SB-300C8 column can be used for determination of drug to antibody distribution in ADCs derived from both IgG1 and IgG2 antibody intermediates