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The Agilent AdvanceBio SEC column together with the Agilent 1260 Infinity II Bio-inert System is an ideal combination for the aggregate analysis of ADCs
Size exclusion chromatography/mass spectrometry analysis of antibody drug conjugates using the Agilent 1260 Infinity II Bio-Inert LC
Fraction analysis of cysteine-linked antibody-drug conjugates using hydrophobic interaction chromatography on the Agilent 1260 Infinity II Bio-Inert LC system.
Identification of monoclonal antibody mutation sites using the 1290 Infinity II 2D-LC solution with 6530 Q-TOF LC/MS.
Online user guide for AdvanceBio Spin columns and 96-sample plates for buffer exchange or desalting of proteins or oligonucleotides.
| Japanese (Japan) | Complete (PDF) |
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| Chinese (Simplified) (China) | Complete (PDF) |
This application note describes a method for identification of the free drug content of an ADC sample using 2D-LC/Q-TOF.
| Korean (Korea) | Complete (PDF) |
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This application note demonstrates the benefits of the Agilent Cary 3500 UV-Vis Multicell spectrophotometer for analysis of drug-to-antibody ratio and aggregation index of ADCs.
| Korean (Korea) | Complete (PDF) |
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| Spanish (Spain) | Complete (PDF) |
| Japanese (Japan) | Complete (PDF) |
| French (France) | Complete (PDF) |
| Chinese (Simplified) (China) | Complete (PDF) |
| German (Germany) | Complete (PDF) |
| Italian (Italy) | Complete (PDF) |
This application note demonstrates the drug-to-antibody (DAR) determination of brentuximab vedotin using a ternary gradient with the Agilent Infinity II Prime Bio LC.
| Chinese (Simplified) (China) | Complete (PDF) |
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Comparing maps of a mAb and its conjugates with the AdvanceBio Peptide Mapping column identifies peptides conjugated with a cytotoxic drug in an ADC digest.
Analysis of tryptic digests of a monoclonal antibody and an antibody-drug conjugate with the Agilent 1290 Infinity II LC
In this application note, we have developed a mass spectrometry-compatible, native-mode size exclusion (SEC/MS) method for characterization of a challenging FDC with very low pI.
| German (Germany) | Complete (PDF) |
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| French (France) | Complete (PDF) |
| Spanish (Spain) | Complete (PDF) |
| Chinese (Simplified) (China) | Complete (PDF) |
| Italian (Italy) | Complete (PDF) |
| Korean (Korea) | Complete (PDF) |
| Japanese (Japan) | Complete (PDF) |
This application note demonstrates the DAR determination of brentuximab vedotin using HIC.
| Chinese (Simplified) (China) | Complete (PDF) |
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This application note describes a robust LC/MS method for the analysis of native mAb-siRNA conjugates.
This study determines the efficiency gains associated with using fluorescence analysis to complement size exclusion chromatography for aggregation analysis
Describes a comparison between the Agilent AdvanceBio SEC 200 ? 1.9 μm column and other vendors' SEC columns in terms of mAb and ADC analysis.
| Japanese (Japan) | Complete (PDF) |
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| Chinese (Simplified) (China) | Complete (PDF) |
This app note presents a complete high-throughput workflow solution to analyze a variety of mAb products.
| Chinese (Simplified) (China) | Complete (PDF) |
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| Japanese (Japan) | Complete (PDF) |
Presents the use of the Agilent Bio SEC-3 column to aid HRMS characterization of mAbs and ADCs.
Presents the use of AdvanceBio Desalting-RP cartridges to pretreat mAb and ADC samples before MS analysis.
Methods using Agilent AdvanceBio SEC columns are developed for the characterization of components of standard protein mixtures.
| Japanese (Japan) | Complete (PDF) |
|---|---|
| Chinese (Simplified) (China) | Complete (PDF) |