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Streamlined workflows for N-Glycan analysis of biotherapeutics using Agilent AdvanceBio Gly-X InstantPC and 2-AB Express sample preparation with LC/FLD/MS
The development and manufacturing of biosimilars require comparability studies with innovator biotherapeutic products.
| Korean (Korea) | Complete (PDF) |
|---|---|
| Chinese (Simplified) (China) | Complete (PDF) |
A Comparative Study of the Intact Mass, Subunit Mass, and Released Glycans of Two Rituximab Biosimilars Using High-Resolution LC/MS
| Chinese (Simplified) (China) | Complete (PDF) |
|---|---|
| Korean (Korea) | Complete (PDF) |
This application note describes a novel 2D-LC approach using MHC and subsequent SEC desalting for native MS analysis.
Agilent's RapidFire High-throughput Mass Spectrometry system utilizes the Q-TOF MS to speed up metabolic stability data analysis by eliminating the need for MRM optimization.
This application note presents different approaches to native mass spectrometry.
Sensitive, high-resolution LC/MS/MS method using the Agilent 6546 LC/Q-TOF for the detection and quantification of the nitrosamine impurities
| Japanese (Japan) | Complete (PDF) |
|---|---|
| Chinese (Simplified) (China) | Complete (PDF) |
| Korean (Korea) | Complete (PDF) |
This application note describes a robust LC/MS method for the analysis of native mAb-siRNA conjugates.
This application note describes a robust LC/MS method for the analysis of native protein analysis.
Describes a workflow for monitoring multiple mAb characteristics involving the Agilent 1290 Infinity II 2D-LC System.
This application note presents the use of the Agilent 6560 ion mobility LC/Q-TOF to analyze the formation of multimers of bovine serum albumin (BSA) in various mobile phases.
This application note describes a sensitive, high-resolution LC/MS/MS method using the 6546 LC/Q-TOF for the detection and quantification of NDMA in ranitidine drug substance and products.
| Chinese (Simplified) (China) | Complete (PDF) |
|---|---|
| Korean (Korea) | Complete (PDF) |
| Japanese (Japan) | Complete (PDF) |
An automated workflow for the analysis of protein phosphorylation from sample preparation with phosphopeptide enrichment to analysis by IMS.
The development and manufacturing of biosimilars require comparability studies with innovator biotherapeutic products.
| Korean (Korea) | Complete (PDF) |
|---|---|
| Chinese (Simplified) (China) | Complete (PDF) |
This application note describes a method for quantitative analysis of intact monoclonal antibodies (mAbs) in a serum matrix.
Presents the use of the Agilent 7100 CE Instrument with MS detection for direct MS determination of monoclonal antibody charge variants.
| Chinese (Simplified) (China) | Complete (PDF) |
|---|---|
| Japanese (Japan) | Complete (PDF) |
This app note presents a complete high-throughput workflow solution to analyze a variety of mAb products.
| Chinese (Simplified) (China) | Complete (PDF) |
|---|---|
| Japanese (Japan) | Complete (PDF) |
Presents the use of the Agilent Bio SEC-3 column to aid HRMS characterization of mAbs and ADCs.
Presents the use of AdvanceBio Desalting-RP cartridges to pretreat mAb and ADC samples before MS analysis.
An Agilent LC system, ZORBAX column and optimized LC gradient were used for fast separation of blood plasma lipids with 15 minutes cycle time injection-to injection.