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End-to-End Workflow Solutions for Oligonucleotide Analysis. From research discovery to production QA/QC.
Polymeric particles, such as PLRP-S and PL-SAX, are ideal for analyzing and purifying oligonucleotides. Because these materials are thermally and chemically stable, they enable diverse techniques.
A guide to find the right column for your characterization workflow. It includes advice and tips on method development, solvent choice, mobile phase modification, optimization, example separations, as well as ordering information.
This application note demonstrates the utility of Agilent Bio SAX columns for oligonucleotide analysis and provides suggested starting points for further method development.
Information and tips on installing and using Agilent PLRP-S, PL-SAX, and PL-SCX preparative LC columns
In this application note, a method for the purification of oligonucleotides is described, utilizing TRIS and Automated Purification Software, in place of the more costly HFIP reagent.
This application note demonstrates an oligonucleotide sequence confirmation workflow using Agilent BioConfirm software with an Agilent 1290 Infinity II LC and Agilent 6545XT AdvanceBio LC/Q-TOF.
This application note describes the characterization of product?related impurities in the development of new oligonucleotide biotherapeutics using LC/(Q)-TOF and MassHunter BioConfirm software.
This application note describes common method parameters that can be optimized when purifying oligonucleotides ranging from 25 to 100 bases in length.
This technical overview is intended to provide guidance for the correct choice of pore size depending on the size of oligonucleotide you are working with.
Rapid mRNA capping analysis with a combined sample preparation and analysis time of only 75 minutes using an Agilent 6545XT AdvanceBio LC/Q-TOF.
PEEK-lined columns and bio-inert supplies to complement the Agilent 1290 Infinity II Bio LC system
This application note demonstrates the purification workflow of a single-stranded RNA ON by ion-pair reversed-phase HPLC.
Critical Quality Attributes Charge Variant compendium
Application compendium for intact and subunit purity
Anion-exchange chromatography for the analysis and purification of oligonucleotides using a PL-SAX column.
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Use of 6545XT LC/Q-TOF to analyze poly-A tail sequences formed by E. coli Poly-A Polymerase (PAP), which is a common component of in vitro transcription systems.
This application note shows that there are numerous variables available for optimization of the analytical conditions for oligonucleotides. The analyses were carried out on an Agilent 1290 Infinity II LC System with UV detection by DAD and an...
This app note presents a complete high-throughput workflow solution to analyze a variety of mAb products.
An Integrated Workflow for Intact and Subunits of Monoclonal Antibody Accurate Mass Measurements