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The enzyme l-asparaginase poses a challenge for quantifying aggregation as its structure may produce high molecular weight aggregates.
An SEC method identifying innovator and biosimilar insulin analog was developed using an Agilent AdvanceBio SEC 130?, 7.8 × 300 mm, 2.7 μm column.
Evaluation of SEC Columns for Analysis of ADC Aggregates and Fragments - Choosing the best stationary phase to overcome nonspecific interactions.
This collection of 10 Agilent ‘a(chǎn)ggregate and fragment analysis’ app notes also includes our guide on how to perform SEC for biomolecule analysis.
An overview of the separation and characterization of Emicizumab, using a variety of products from the Agilent biocolumns portfolio.
In this application note, we have developed a mass spectrometry-compatible, native-mode size exclusion (SEC/MS) method for characterization of a challenging FDC with very low pI.
Nanobody analysis with AdvanceBio SEC 120 ? 1.9 μm column for size exclusion chromatography and AdvanceBio HIC column hydrophobic interaction chromatography (HIC)
Comparison of AdvanceBio SEC 200 ? 1.9 μm column for SEC analysis of hGH, hG-CSF and IFN alpha-2b therapeutic proteins with sub-2 μm particle columns from other vendors.
Presents a method for the rapid analysis of a monoclonal antibody using the Agilent AdvanceBio SEC 200 ? 19 μm column.
Comparison of HPLC method and a quick method developed using the Cary 60 UV-Vis
This application note describes a robust LC/MS method for the analysis of native protein analysis.
Improvements in resolution and shorter run times using AdvanceBio SEC 120 ? 1.9 μm, 4.6 x 300 mm column for insulin analysis.
Size Exclusion Chromatography Method Development of NIST mAb Using an Agilent AdvanceBio SEC 200 ?, 1.9 μm Column
Describes a comparison between the Agilent AdvanceBio SEC 200 ? 1.9 μm column and other vendors' SEC columns in terms of mAb and ADC analysis.
Size exclusion chromatography with light scattering detection was used to investigate the impact of varying SDS concentration on protein molecules.
An aggregate analysis workflow for SEC mobile phase optimization and characterization of mAb aggregation profiles
"This Application Note describes the quantification of aggregates in biotherapeutic
Agilent AdvanceBioSEC columns used for fast, high resolution, sensitive, and reproducible separation and quantitation of mAbs and Antibody Drug Conjugate,
Online 2D-LC characterization of monoclonal antibodies using SEC in the first dimension and IEX in the second dimension
A SEC method for determining the purity of PEG Granulocyte Colony Stimulating Factor using an Agilent AdvanceBio SEC column with aqueous mobile phase.