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Comparing maps of a mAb and its conjugates with the AdvanceBio Peptide Mapping column identifies peptides conjugated with a cytotoxic drug in an ADC digest.
In this application note, we have developed a mass spectrometry-compatible, native-mode size exclusion (SEC/MS) method for characterization of a challenging FDC with very low pI.
Describes a comparison between the Agilent AdvanceBio SEC 200 ? 1.9 μm column and other vendors' SEC columns in terms of mAb and ADC analysis.
This app note presents a complete high-throughput workflow solution to analyze a variety of mAb products.
Presents the use of AdvanceBio Desalting-RP cartridges to pretreat mAb and ADC samples before MS analysis.
Describes the use of the new AdvanceBio HIC column, with method optimization, to assess DAR values of ADCs.
Agilent PLRP-S column demonstrates superior separation performance for the analysis of mAbs and ADC at both intact and fragment levels
Agilent AdvanceBioSEC columns used for fast, high resolution, sensitive, and reproducible separation and quantitation of mAbs and Antibody Drug Conjugate,
Using Multiple Heart-cutting Hydrophobic Interaction/Reversed Phase 2D-LC/MS
In this paper, we are investigating an antibody drug conjugate (ADC) with a cysteine linker.
Analysis of an mAb (trastuzumab) and an ADC (trastuzumab emtansine) by size exclusion chromatography with online mass spectrometry (SEC-MS)
Analyzing therapeutic mAbs with AdvancedBio RP-mAb and a 6530 Accurate-Mass Q-TOF LC/MS delivers fast and high-resolution separation of intact and ADC mAbs.