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This application note presents a streamlined LC/MS workflow for ASO purity assessment using the Agilent InfinityLab Pro iQ Plus LC/MS system and Oligo Analysis Accelerator (OAA) software for Agilent OpenLab CDS.
In this application note, HILIC is introduced as an orthogonal methodology and applied to the analysis of Exenatide, Semaglutide, and Tirzepatide.
This guide is valid for LC/SQ Mass Detector systems running OpenLab CDS 2.7 or 2.8 with LC/MS Driver 3.2
Release notes for the LC/SQ driver
LC/MS-based method for assessing the purity of an antisense oligonucleotide
Site preparation checklist for the InfinityLab Pro iQ Series LC/SQ mass detectors
To get you started and to assure a successful and timely installation, please refer to this specification or set of requirements.
This application note confirms the aggregates of liraglutide and semaglutide through size exclusion chromatography using an Agilent 1290 Infinity II Bio LC system and InfinityLab LC/MSD XT.
This application note presents the analysis of peptide-related impurities for semaglutide with the Agilent 1290 Infinity II bio 2D-LC and InfinityLab LC/MSD XT.
This application note highlights the analysis and identification of impurities arising from stability assays with GLP-1 agonist peptides.
This application note utilizes the 1260 Infinity II Bio Prime LC and InfinityLab LC/MSD iQ for the confirmation of GLP-1 (Liraglutide) sample.
Molecular weight confirmation and simple characterization workflows for synthetic oligos with Agilent LC/MSD XT and MS Spectral Deconvolution feature in OpenLab CDS 2.8.
This guide provides an overview of the daily workflow using OpenLab CDS software
The novel approach presented in this method utilizes standard chromatographic methods and simple cost-effective single quadrupole mass spectrometer without sacrificing accuracy for the screening and quantitation of histamines in Gentamicin matrices.
Accurate Mass Full Spectral Monitoring and Analysis of Both the Analyte and Reference Standard with Ion Chromatography – Mass Spectrometry.
A robust microflow method for oligonucleotide analysis which dramatically reduces the consumption of HFIP and TEA. Carried out using the Axcend Focus LC ? coupled with the Agilent LC/MSD Pro iQ Plus.
A robust and cost-effective single quadrupole mass spectrometer reports on glycosylation relative abundances for monoclonal antibodies.
This study evaluates the stability of tirzepatide and semaglutide under various pH and storage conditions using the Agilent InfinityLab Pro iQ Plus LC/MS system.
This poster is a demonstration of Pro iQ Plus robustness & ruggedness against these factors over a series of 800 consecutive injections of analytes spiked in crashed plasma matrix.
Establish correlations between abundance settling time and changes in multiple acquisition parameters from empirical data. Apply the correlations to ensure instrument performance at a high sampling rate with minimal inter-measurement delays.