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In this work we evaluate four-dimensional feature finding algorithms (vendor and third party) as well as methods for aligning precursor and fragment ions across various chemical species including lipid, proteomics, and PFAS data.
In-source chemical charge reduction allows precise control over protein charge distributions. This work explores the influence of charge reduction on protein structure and top-down fragmentation.
Ion mobility with high resolution mass spectrometry provides an additional dimension to differentiate between isobaric acylcarnitine isomers allowing fast analysis.